Proteomics in Pathology

Pharmaceutical Advances and Proteomics Researches

Proteomics enables understanding the composition, structure, function and interactions of the entire protein complement of a cell, a tissue, or an organism under exactly defined conditions. Some factors such as stress or drug effects will change the protein pattern and cause the present or absence of a protein or gradual variation in abundances. Changes in the proteome provide a snapshot of the...

Proteomics in diagnostic pathology: profiling and imaging proteins directly in tissue sections.

Direct tissue profiling and imaging mass spectrometry (MS) provide a molecular assessment of numerous expressed proteins within a tissue sample. MALDI MS (matrix-assisted laser desorption ionization) analysis of thin tissue sections results in the visualization of 500 to 1000 individual protein signals in the molecular weight range from 2000 to over 200,000. These signals directly correlate wit...

Application of Proteomics Technologies in the Drug Development Process

Diagnostic molecular pathology, part 2: proteomics and clinical applications of molecular diagnostics in hematopathology.

VOLUME 18, NUMBER 16 7 BUMC PROCEEDINGS 2005;18:7–12 Currently, molecular diagnostics plays an important role in the clinical management of a wide array of hematologic neoplasms, solid tumors, infectious diseases, and inherited genetic disorders. In this second part of our series, we conclude our review of esoteric techniques by summarizing some of the advances in the field of “proteomics.” We ...

Application of Proteomics Technologies in the Drug Development Process